Recent advances in quantum information science have shed light on the intricate dynamics of quantum many-body systems, for which quantum information scrambling is a perfect example. Motivated by considerations of the thermodynamics of quantum information, this perspective aims at synthesizing key findings from several pivotal studies and exploring various aspects of quantum scrambling. We consider quantifiers such as the Out-of-Time-Ordered Correlator (OTOC), the quantum Mutual Information, and the Tripartite Mutual Information (TMI), their connections to thermodynamics, and their role in understanding chaotic versus integrable quantum systems. With a focus on representative examples, we cover a range of topics, including the thermodynamics of quantum information scrambling, and the scrambling dynamics in quantum gravity models such as the Sachdev-Ye-Kitaev (SYK) model. Examining these diverse approaches enables us to highlight the multifaceted nature of quantum information scrambling and its significance in understanding the fundamental aspects of quantum many-body dynamics at the intersection of quantum mechanics and thermodynamics.