Controlled quantum machines have matured significantly. A natural next step is to increasingly grant them autonomy, freeing them from time-dependent external control. For example, autonomy could pare down the classical control wires that heat and decohere quantum circuits; and an autonomous quantum refrigerator recently reset superconducting qubits to near their ground states, as is necessary before a computation. Which fundamental conditions are necessary for realizing useful autonomous quantum machines? Inspired by recent quantum thermodynamics and chemistry, we posit conditions analogous to DiVincenzo’s criteria for quantum computing. Furthermore, we illustrate the criteria with multiple autonomous quantum machines (refrigerators, circuits, clocks, etc.) and multiple candidate platforms (neutral atoms, molecules, superconducting qubits, etc.). Our criteria are intended to foment and guide the development of useful autonomous quantum machines.